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Core Sequencing Technologies

Built for Precision. Designed for Performance.

Powered by proprietary sequencing chemistry and precision fluidics, our technologies deliver high-accuracy sequencing, streamlined workflows, and lower operating costs.

LumoSeq Technology

Fluorogenic Chemistry for Accurate, Scar-Free Sequencing

LumoSeq leverages nucleotide substrates with a unique fluorogenic mechanism, delivering >1,000× signal enhancement between their dark and bright states.

During DNA synthesis, the polymerase incorporates dark-state nucleotides, enabling the synthesis of native DNA without molecular scars, while releasing the fluorophore into its bright state. Four bases are encoded by four distinct fluorescence intensity levels.

An advanced optical system captures these high-contrast signals with an exceptionally high signal-to-noise ratio (SNR), enabling accurate and reliable decoding of DNA sequences.

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LoopChip Technology

Layer On/Off Patterning for Reusable Sequencing Chips

Powered by AttoSeal’s sub-micron precision fluidic control, LoopChip enables precise and controllable chemical processing across billions of microwells on a sequencing chip.

Following a sequencing run, LoopChip enables thorough cleaning and regeneration of the used chip, allowing a fresh patterned array to be regenerated for subsequent sequencing.

By enabling repeated use of the sequencing chip, LoopChip helps significantly reduce sequencing costs while maintaining consistent sequencing performance across runs.

Technology Highlights

High Accuracy

Exceptional fluorescence signal-to-noise ratio enables precise base discrimination and highly accurate sequencing.

Native DNA Sequencing

Polymerase synthesizes native DNA without molecular scars, minimizing interference from chemical modifications.

No Balancing Library Required

No library balancing required, even for low-complexity or base-imbalanced libraries, enabling simpler preparation and more efficient workflows.

Reusable Sequencing Chips

LoopChip technology enables repeated chip regeneration while maintaining consistent sequencing performance, reducing consumable costs and minimize DNA carryover between runs.